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KMID : 0350519950480010279
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.279 ~ p.289
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Relationship between Expression of Mutated Tumor Suppressor Gene(p53, Rb) and Recurrence in Superficial Bladder Carcinoma
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Abstract
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We examined the deparaffinized tumor tissue specimens from transurethral resection in 43 patients with superficial bladder cancer(stage Pa, P1). Nuclear overexpression of p53 protein and altered expression of Rb protein were examined by
immunohistochemical analysis using mouse monoclonal antibody. The data were then evaluated with tumor stage, grade, resurrence and recurrence-free intervals of the patients.
@ES The results were as follows :
@EN 1. Expression rate of mutated p53 or Rb gene was significantly increased in bladder carcinoma group compared with that normal control group(P=.046, P=.002).
2. Expression rate of mutated p53 gene was significantly correlated with tumor stage(P=.045), but expression rate of mutated Rb gene was not(P=.392).
3. Expression rate of mutated p53 or Rb gene was not significantly correlated with tumor grade(P=.198, P=.747).
4. Expression of mutated p53 or Rb gene was significantly increased in recurrence cases compared with that in nin-recurrence cases(P=.018, P=.010).
5. Recurrence was significantly increased in mutated p53 or Rb expression cases compared with that in normal p53 or Rb expression cases(P=.018, P=.010).
6. Recurrence-free interval was significantly short in mutated p53 and Rb gene cases compared with that in normal expression cases9P=.046, P=.0310).
These results suggested that probability of recurrence would be high in superficial bladder cancer patients who expressed mutated p53 or Rb gene compared with that of normal genes after transurethral resection of the bladder carcinoma.
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